31:Premier League fixtures 2021-22
Manchester City will begin their Premier League title defence at Tottenham. Pep Guardiola's side won their third top-flight crown in four seasons in 2020-21 and there is likely to be plenty of intrigue in the build-up to the August 14 encounter at Tottenham Hotspur Stadium, given Spurs striker Harry Kane has been touted as a potential replacement for Sergio Aguero.
Chelsea denied City European glory with a 1-0 win in last month's Champions League final and Thomas Tuchel's side start their bid to unseat Guardiola's men domestically by hosting Crystal Palace, who like Spurs remain without a manager.
Manchester United were runners-up last term and Ole Gunnar Solskjaer's third full season in charge will launch with a mouth-watering clash against Marcelo Bielsa's Leeds United at Old Trafford.
Newly promoted Brentford have a similarly eye-catching assignment at home to Arsenal, who have no European commitments for the first time since 1995-96.
Liverpool are also away to one of the newcomers in the form of Championship winners Norwich City. While newly-promoted Watford host Aston Villa on their top-flight return.
Tricky start for Guardiola, Tuchel facing January Blues
City claimed a first victory at Anfield since 2003 last season and Jurgen Klopp will enjoy his latest battle with Pep Guardiola on Merseyside on October 2, a week after the champions get their shot at revenge over Chelsea at Stamford Bridge.
Those matches all come within City's first seven fixtures, which also include Arsenal visiting the Etihad Stadium on August 28, the same day Chelsea travel to Liverpool and a week after Mikel Arteta's men welcome the European champions.
The season's first Manchester United v Liverpool encounter comes at Old Trafford on October 23, two weeks before United host City in the Manchester derby.
The return meetings for those two rivalries are at Anfield on March 19 and the Etihad Stadium on March 5.
Those games could prove key to the title run-in, much like Chelsea's trip to Old Trafford on the penultimate weekend.
The Blues have a tough January schedule, with Liverpool at Stamford Bridge on New Year's Day, followed by City away a fortnight later and a home derby against Tottenham.
Spurs and Arsenal are each aiming to improve upon dispiriting campaigns last time around. The first north London derby of the season is at Emirates Stadium on September 25, with Tottenham hosting their neighbours on January 15.
In full: All the 2021/22 Premier League fixtures
| 14/08/2021 | 15:00 | Brentford v Arsenal |
| 14/08/2021 | 15:00 | Burnley v Brighton |
| 14/08/2021 | 15:00 | Chelsea v Crystal Palace |
| 14/08/2021 | 15:00 | Everton v Southampton |
| 14/08/2021 | 15:00 | Leicester City v Wolverhampton |
| 14/08/2021 | 15:00 | Manchester United v Leeds United |
| 14/08/2021 | 15:00 | Newcastle United v West Ham United |
| 14/08/2021 | 15:00 | Norwich City v Liverpool |
| 14/08/2021 | 15:00 | Tottenham Hotspur v Manchester City |
| 14/08/2021 | 15:00 | Watford v Aston Villa |
| 21/08/2021 | 15:00 | Arsenal v Chelsea |
| 21/08/2021 | 15:00 | Aston Villa v Newcastle United |
| 21/08/2021 | 15:00 | Brighton v Watford |
| 21/08/2021 | 15:00 | Crystal Palace v Brentford |
| 21/08/2021 | 15:00 | Leeds United v Everton |
| 21/08/2021 | 15:00 | Liverpool v Burnley |
| 21/08/2021 | 15:00 | Manchester City v Norwich City |
| 21/08/2021 | 15:00 | Southampton v Manchester United |
| 21/08/2021 | 15:00 | West Ham United v Leicester City |
| 21/08/2021 | 15:00 | Wolverhampton v Tottenham Hotspur |
| 28/08/2021 | 15:00 | Aston Villa v Brentford |
| 28/08/2021 | 15:00 | Brighton v Everton |
| 28/08/2021 | 15:00 | Burnley v Leeds United |
| 28/08/2021 | 15:00 | Liverpool v Chelsea |
| 28/08/2021 | 15:00 | Manchester City v Arsenal |
| 28/08/2021 | 15:00 | Newcastle United v Southampton |
| 28/08/2021 | 15:00 | Norwich City v Leicester City |
| 28/08/2021 | 15:00 | Tottenham Hotspur v Watford |
| 28/08/2021 | 15:00 | West Ham United v Crystal Palace |
| 28/08/2021 | 15:00 | Wolverhampton v Manchester United |
| 11/09/2021 | 15:00 | Arsenal v Norwich City |
| 11/09/2021 | 15:00 | Brentford v Brighton |
| 11/09/2021 | 15:00 | Chelsea v Aston Villa |
| 11/09/2021 | 15:00 | Crystal Palace v Tottenham Hotspur |
| 11/09/2021 | 15:00 | Everton v Burnley |
| 11/09/2021 | 15:00 | Leeds United v Liverpool |
| 11/09/2021 | 15:00 | Leicester City v Manchester City |
| 11/09/2021 | 15:00 | Manchester United v Newcastle United |
| 11/09/2021 | 15:00 | Southampton v West Ham United |
| 11/09/2021 | 15:00 | Watford v Wolverhampton |
| 18/09/2021 | 15:00 | Aston Villa v Everton |
| 18/09/2021 | 15:00 | Brighton v Leicester City |
| 18/09/2021 | 15:00 | Burnley v Arsenal |
| 18/09/2021 | 15:00 | Liverpool v Crystal Palace |
| 18/09/2021 | 15:00 | Manchester City v Southampton |
| 18/09/2021 | 15:00 | Newcastle United v Leeds United |
| 18/09/2021 | 15:00 | Norwich City v Watford |
| 18/09/2021 | 15:00 | Tottenham Hotspur v Chelsea |
| 18/09/2021 | 15:00 | West Ham United v Manchester United |
| 18/09/2021 | 15:00 | Wolverhampton v Brentford |
| 25/09/2021 | 15:00 | Arsenal v Tottenham Hotspur |
| 25/09/2021 | 15:00 | Brentford v Liverpool |
| 25/09/2021 | 15:00 | Chelsea v Manchester City |
| 25/09/2021 | 15:00 | Crystal Palace v Brighton |
| 25/09/2021 | 15:00 | Everton v Norwich City |
| 25/09/2021 | 15:00 | Leeds United v West Ham United |
| 25/09/2021 | 15:00 | Leicester City v Burnley |
| 25/09/2021 | 15:00 | Manchester United v Aston Villa |
| 25/09/2021 | 15:00 | Southampton v Wolverhampton |
| 25/09/2021 | 15:00 | Watford v Newcastle United |
| 02/10/2021 | 15:00 | Brighton v Arsenal |
| 02/10/2021 | 15:00 | Burnley v Norwich City |
| 02/10/2021 | 15:00 | Chelsea v Southampton |
| 02/10/2021 | 15:00 | Crystal Palace v Leicester City |
| 02/10/2021 | 15:00 | Leeds United v Watford |
| 02/10/2021 | 15:00 | Liverpool v Manchester City |
| 02/10/2021 | 15:00 | Manchester United v Everton |
| 02/10/2021 | 15:00 | Tottenham Hotspur v Aston Villa |
| 02/10/2021 | 15:00 | West Ham United v Brentford |
| 02/10/2021 | 15:00 | Wolverhampton v Newcastle United |
| 16/10/2021 | 15:00 | Arsenal v Crystal Palace |
| 16/10/2021 | 15:00 | Aston Villa v Wolverhampton |
| 16/10/2021 | 15:00 | Brentford v Chelsea |
| 16/10/2021 | 15:00 | Everton v West Ham United |
| 16/10/2021 | 15:00 | Leicester City v Manchester United |
| 16/10/2021 | 15:00 | Manchester City v Burnley |
| 16/10/2021 | 15:00 | Newcastle United v Tottenham Hotspur |
| 16/10/2021 | 15:00 | Norwich City v Brighton |
| 16/10/2021 | 15:00 | Southampton v Leeds United |
| 16/10/2021 | 15:00 | Watford v Liverpool |
| 23/10/2021 | 15:00 | Arsenal v Aston Villa |
| 23/10/2021 | 15:00 | Brentford v Leicester City |
| 23/10/2021 | 15:00 | Brighton v Manchester City |
| 23/10/2021 | 15:00 | Chelsea v Norwich City |
| 23/10/2021 | 15:00 | Crystal Palace v Newcastle United |
| 23/10/2021 | 15:00 | Everton v Watford |
| 23/10/2021 | 15:00 | Leeds United v Wolverhampton |
| 23/10/2021 | 15:00 | Manchester United v Liverpool |
| 23/10/2021 | 15:00 | Southampton v Burnley |
| 23/10/2021 | 15:00 | West Ham United v Tottenham Hotspur |
| 30/10/2021 | 15:00 | Aston Villa v West Ham United |
| 30/10/2021 | 15:00 | Burnley v Brentford |
| 30/10/2021 | 15:00 | Leicester City v Arsenal |
| 30/10/2021 | 15:00 | Liverpool v Brighton |
| 30/10/2021 | 15:00 | Manchester City v Crystal Palace |
| 30/10/2021 | 15:00 | Newcastle United v Chelsea |
| 30/10/2021 | 15:00 | Norwich City v Leeds United |
| 30/10/2021 | 15:00 | Tottenham Hotspur v Manchester United |
| 30/10/2021 | 15:00 | Watford v Southampton |
| 30/10/2021 | 15:00 | Wolverhampton v Everton |
| 06/11/2021 | 15:00 | Arsenal v Watford |
| 06/11/2021 | 15:00 | Brentford v Norwich City |
| 06/11/2021 | 15:00 | Brighton v Newcastle United |
| 06/11/2021 | 15:00 | Chelsea v Burnley |
| 06/11/2021 | 15:00 | Crystal Palace v Wolverhampton |
| 06/11/2021 | 15:00 | Everton v Tottenham Hotspur |
| 06/11/2021 | 15:00 | Leeds United v Leicester City |
| 06/11/2021 | 15:00 | Manchester United v Manchester City |
| 06/11/2021 | 15:00 | Southampton v Aston Villa |
| 06/11/2021 | 15:00 | West Ham United v Liverpool |
| 20/11/2021 | 15:00 | Aston Villa v Brighton |
| 20/11/2021 | 15:00 | Burnley v Crystal Palace |
| 20/11/2021 | 15:00 | Leicester City v Chelsea |
| 20/11/2021 | 15:00 | Liverpool v Arsenal |
| 20/11/2021 | 15:00 | Manchester City v Everton |
| 20/11/2021 | 15:00 | Newcastle United v Brentford |
| 20/11/2021 | 15:00 | Norwich City v Southampton |
| 20/11/2021 | 15:00 | Tottenham Hotspur v Leeds United |
| 20/11/2021 | 15:00 | Watford v Manchester United |
| 20/11/2021 | 15:00 | Wolverhampton v West Ham United |
| 27/11/2021 | 15:00 | Arsenal v Newcastle United |
| 27/11/2021 | 15:00 | Brentford v Everton |
| 27/11/2021 | 15:00 | Brighton v Leeds United |
| 27/11/2021 | 15:00 | Burnley v Tottenham Hotspur |
| 27/11/2021 | 15:00 | Chelsea v Manchester United |
| 27/11/2021 | 15:00 | Crystal Palace v Aston Villa |
| 27/11/2021 | 15:00 | Leicester City v Watford |
| 27/11/2021 | 15:00 | Liverpool v Southampton |
| 27/11/2021 | 15:00 | Manchester City v West Ham United |
| 27/11/2021 | 15:00 | Norwich City v Wolverhampton |
| 30/11/2021 | 19:45 | Aston Villa v Manchester City |
| 30/11/2021 | 19:45 | Everton v Liverpool |
| 30/11/2021 | 19:45 | Leeds United v Crystal Palace |
| 30/11/2021 | 20:00 | Manchester United v Arsenal |
| 30/11/2021 | 19:45 | Watford v Chelsea |
| 30/11/2021 | 19:45 | West Ham United v Brighton |
| 30/11/2021 | 19:45 | Wolverhampton v Burnley |
| 01/12/2021 | 19:45 | Newcastle United v Norwich City |
| 01/12/2021 | 19:45 | Southampton v Leicester City |
| 01/12/2021 | 19:45 | Tottenham Hotspur v Brentford |
| 04/12/2021 | 15:00 | Aston Villa v Leicester City |
| 04/12/2021 | 15:00 | Everton v Arsenal |
| 04/12/2021 | 15:00 | Leeds United v Brentford |
| 04/12/2021 | 15:00 | Manchester United v Crystal Palace |
| 04/12/2021 | 15:00 | Newcastle United v Burnley |
| 04/12/2021 | 15:00 | Southampton v Brighton |
| 04/12/2021 | 15:00 | Tottenham Hotspur v Norwich City |
| 04/12/2021 | 15:00 | Watford v Manchester City |
| 04/12/2021 | 15:00 | West Ham United v Chelsea |
| 04/12/2021 | 15:00 | Wolverhampton v Liverpool |
| 11/12/2021 | 15:00 | Arsenal v Southampton |
| 11/12/2021 | 15:00 | Brentford v Watford |
| 11/12/2021 | 15:00 | Brighton v Tottenham Hotspur |
| 11/12/2021 | 15:00 | Burnley v West Ham United |
| 11/12/2021 | 15:00 | Chelsea v Leeds United |
| 11/12/2021 | 15:00 | Crystal Palace v Everton |
| 11/12/2021 | 15:00 | Leicester City v Newcastle United |
| 11/12/2021 | 15:00 | Liverpool v Aston Villa |
| 11/12/2021 | 15:00 | Manchester City v Wolverhampton |
| 11/12/2021 | 15:00 | Norwich City v Manchester United |
| 14/12/2021 | 19:45 | Arsenal v West Ham United |
| 14/12/2021 | 19:45 | Brentford v Manchester United |
| 14/12/2021 | 19:45 | Brighton v Wolverhampton |
| 14/12/2021 | 19:45 | Burnley v Watford |
| 14/12/2021 | 20:00 | Crystal Palace v Southampton |
| 14/12/2021 | 19:45 | Leicester City v Tottenham Hotspur |
| 14/12/2021 | 19:45 | Norwich City v Aston Villa |
| 15/12/2021 | 20:00 | Chelsea v Everton |
| 15/12/2021 | 20:00 | Liverpool v Newcastle United |
| 15/12/2021 | 20:00 | Manchester City v Leeds United |
| 18/12/2021 | 15:00 | Aston Villa v Burnley |
| 18/12/2021 | 15:00 | Everton v Leicester City |
| 18/12/2021 | 15:00 | Leeds United v Arsenal |
| 18/12/2021 | 15:00 | Manchester United v Brighton |
| 18/12/2021 | 15:00 | Newcastle United v Manchester City |
| 18/12/2021 | 15:00 | Southampton v Brentford |
| 18/12/2021 | 15:00 | Tottenham Hotspur v Liverpool |
| 18/12/2021 | 15:00 | Watford v Crystal Palace |
| 18/12/2021 | 15:00 | West Ham United v Norwich City |
| 18/12/2021 | 15:00 | Wolverhampton v Chelsea |
| 26/12/2021 | 15:00 | Aston Villa v Chelsea |
| 26/12/2021 | 15:00 | Brighton v Brentford |
| 26/12/2021 | 15:00 | Burnley v Everton |
| 26/12/2021 | 15:00 | Liverpool v Leeds United |
| 26/12/2021 | 15:00 | Manchester City v Leicester City |
| 26/12/2021 | 15:00 | Newcastle United v Manchester United |
| 26/12/2021 | 15:00 | Norwich City v Arsenal |
| 26/12/2021 | 15:00 | Tottenham Hotspur v Crystal Palace |
| 26/12/2021 | 15:00 | West Ham United v Southampton |
| 26/12/2021 | 15:00 | Wolverhampton v Watford |
| 28/12/2021 | 15:00 | Arsenal v Wolverhampton |
| 28/12/2021 | 15:00 | Brentford v Manchester City |
| 28/12/2021 | 15:00 | Chelsea v Brighton |
| 28/12/2021 | 15:00 | Crystal Palace v Norwich City |
| 28/12/2021 | 15:00 | Everton v Newcastle United |
| 28/12/2021 | 15:00 | Leeds United v Aston Villa |
| 28/12/2021 | 15:00 | Leicester City v Liverpool |
| 28/12/2021 | 15:00 | Manchester United v Burnley |
| 28/12/2021 | 15:00 | Southampton v Tottenham Hotspur |
| 28/12/2021 | 15:00 | Watford v West Ham United |
| 01/01/2022 | 15:00 | Arsenal v Manchester City |
| 01/01/2022 | 15:00 | Brentford v Aston Villa |
| 01/01/2022 | 15:00 | Chelsea v Liverpool |
| 01/01/2022 | 15:00 | Crystal Palace v West Ham United |
| 01/01/2022 | 15:00 | Everton v Brighton |
| 01/01/2022 | 15:00 | Leeds United v Burnley |
| 01/01/2022 | 15:00 | Leicester City v Norwich City |
| 01/01/2022 | 15:00 | Manchester United v Wolverhampton |
| 01/01/2022 | 15:00 | Southampton v Newcastle United |
| 01/01/2022 | 15:00 | Watford v Tottenham Hotspur |
| 15/01/2022 | 15:00 | Aston Villa v Manchester United |
| 15/01/2022 | 15:00 | Brighton v Crystal Palace |
| 15/01/2022 | 15:00 | Burnley v Leicester City |
| 15/01/2022 | 15:00 | Liverpool v Brentford |
| 15/01/2022 | 15:00 | Manchester City v Chelsea |
| 15/01/2022 | 15:00 | Newcastle United v Watford |
| 15/01/2022 | 15:00 | Norwich City v Everton |
| 15/01/2022 | 15:00 | Tottenham Hotspur v Arsenal |
| 15/01/2022 | 15:00 | West Ham United v Leeds United |
| 15/01/2022 | 15:00 | Wolverhampton v Southampton |
| 22/01/2022 | 15:00 | Arsenal v Burnley |
| 22/01/2022 | 15:00 | Brentford v Wolverhampton |
| 22/01/2022 | 15:00 | Chelsea v Tottenham Hotspur |
| 22/01/2022 | 15:00 | Crystal Palace v Liverpool |
| 22/01/2022 | 15:00 | Everton v Aston Villa |
| 22/01/2022 | 15:00 | Leeds United v Newcastle United |
| 22/01/2022 | 15:00 | Leicester City v Brighton |
| 22/01/2022 | 15:00 | Manchester United v West Ham United |
| 22/01/2022 | 15:00 | Southampton v Manchester City |
| 22/01/2022 | 15:00 | Watford v Norwich City |
| 08/02/2022 | 19:45 | Aston Villa v Leeds United |
| 08/02/2022 | 19:45 | Brighton v Chelsea |
| 08/02/2022 | 19:45 | Burnley v Manchester United |
| 08/02/2022 | 19:45 | Norwich City v Crystal Palace |
| 08/02/2022 | 19:45 | West Ham United v Watford |
| 08/02/2022 | 19:45 | Wolverhampton v Arsenal |
| 09/02/2022 | 20:00 | Liverpool v Leicester City |
| 09/02/2022 | 20:00 | Manchester City v Brentford |
| 09/02/2022 | 19:45 | Newcastle United v Everton |
| 09/02/2022 | 19:45 | Tottenham Hotspur v Southampton |
| 12/02/2022 | 15:00 | Brentford v Crystal Palace |
| 12/02/2022 | 15:00 | Burnley v Liverpool |
| 12/02/2022 | 15:00 | Chelsea v Arsenal |
| 12/02/2022 | 15:00 | Everton v Leeds United |
| 12/02/2022 | 15:00 | Leicester City v West Ham United |
| 12/02/2022 | 15:00 | Manchester United v Southampton |
| 12/02/2022 | 15:00 | Newcastle United v Aston Villa |
| 12/02/2022 | 15:00 | Norwich City v Manchester City |
| 12/02/2022 | 15:00 | Tottenham Hotspur v Wolverhampton |
| 12/02/2022 | 15:00 | Watford v Brighton |
| 19/02/2022 | 15:00 | Arsenal v Brentford |
| 19/02/2022 | 15:00 | Aston Villa v Watford |
| 19/02/2022 | 15:00 | Brighton v Burnley |
| 19/02/2022 | 15:00 | Crystal Palace v Chelsea |
| 19/02/2022 | 15:00 | Leeds United v Manchester United |
| 19/02/2022 | 15:00 | Liverpool v Norwich City |
| 19/02/2022 | 15:00 | Manchester City v Tottenham Hotspur |
| 19/02/2022 | 15:00 | Southampton v Everton |
| 19/02/2022 | 15:00 | West Ham United v Newcastle United |
| 19/02/2022 | 15:00 | Wolverhampton v Leicester City |
| 26/02/2022 | 15:00 | Arsenal v Liverpool |
| 26/02/2022 | 15:00 | Brentford v Newcastle United |
| 26/02/2022 | 15:00 | Brighton v Aston Villa |
| 26/02/2022 | 15:00 | Chelsea v Leicester City |
| 26/02/2022 | 15:00 | Crystal Palace v Burnley |
| 26/02/2022 | 15:00 | Everton v Manchester City |
| 26/02/2022 | 15:00 | Leeds United v Tottenham Hotspur |
| 26/02/2022 | 15:00 | Manchester United v Watford |
| 26/02/2022 | 15:00 | Southampton v Norwich City |
| 26/02/2022 | 15:00 | West Ham United v Wolverhampton |
| 05/03/2022 | 15:00 | Aston Villa v Southampton |
| 05/03/2022 | 15:00 | Burnley v Chelsea |
| 05/03/2022 | 15:00 | Leicester City v Leeds United |
| 05/03/2022 | 15:00 | Liverpool v West Ham United |
| 05/03/2022 | 15:00 | Manchester City v Manchester United |
| 05/03/2022 | 15:00 | Newcastle United v Brighton |
| 05/03/2022 | 15:00 | Norwich City v Brentford |
| 05/03/2022 | 15:00 | Tottenham Hotspur v Everton |
| 05/03/2022 | 15:00 | Watford v Arsenal |
| 05/03/2022 | 15:00 | Wolverhampton v Crystal Palace |
| 12/03/2022 | 15:00 | Arsenal v Leicester City |
| 12/03/2022 | 15:00 | Brentford v Burnley |
| 12/03/2022 | 15:00 | Brighton v Liverpool |
| 12/03/2022 | 15:00 | Chelsea v Newcastle United |
| 12/03/2022 | 15:00 | Crystal Palace v Manchester City |
| 12/03/2022 | 15:00 | Everton v Wolverhampton |
| 12/03/2022 | 15:00 | Leeds United v Norwich City |
| 12/03/2022 | 15:00 | Manchester United v Tottenham Hotspur |
| 12/03/2022 | 15:00 | Southampton v Watford |
| 12/03/2022 | 15:00 | West Ham United v Aston Villa |
| 19/03/2022 | 15:00 | Aston Villa v Arsenal |
| 19/03/2022 | 15:00 | Burnley v Southampton |
| 19/03/2022 | 15:00 | Leicester City v Brentford |
| 19/03/2022 | 15:00 | Liverpool v Manchester United |
| 19/03/2022 | 15:00 | Manchester City v Brighton |
| 19/03/2022 | 15:00 | Newcastle United v Crystal Palace |
| 19/03/2022 | 15:00 | Norwich City v Chelsea |
| 19/03/2022 | 15:00 | Tottenham Hotspur v West Ham United |
| 19/03/2022 | 15:00 | Watford v Everton |
| 19/03/2022 | 15:00 | Wolverhampton v Leeds United |
| 02/04/2022 | 15:00 | Brighton v Norwich City |
| 02/04/2022 | 15:00 | Burnley v Manchester City |
| 02/04/2022 | 15:00 | Chelsea v Brentford |
| 02/04/2022 | 15:00 | Crystal Palace v Arsenal |
| 02/04/2022 | 15:00 | Leeds United v Southampton |
| 02/04/2022 | 15:00 | Liverpool v Watford |
| 02/04/2022 | 15:00 | Manchester United v Leicester City |
| 02/04/2022 | 15:00 | Tottenham Hotspur v Newcastle United |
| 02/04/2022 | 15:00 | West Ham United v Everton |
| 02/04/2022 | 15:00 | Wolverhampton v Aston Villa |
| 09/04/2022 | 15:00 | Arsenal v Brighton |
| 09/04/2022 | 15:00 | Aston Villa v Tottenham Hotspur |
| 09/04/2022 | 15:00 | Brentford v West Ham United |
| 09/04/2022 | 15:00 | Everton v Manchester United |
| 09/04/2022 | 15:00 | Leicester City v Crystal Palace |
| 09/04/2022 | 15:00 | Manchester City v Liverpool |
| 09/04/2022 | 15:00 | Newcastle United v Wolverhampton |
| 09/04/2022 | 15:00 | Norwich City v Burnley |
| 09/04/2022 | 15:00 | Southampton v Chelsea |
| 09/04/2022 | 15:00 | Watford v Leeds United |
| 16/04/2022 | 15:00 | Aston Villa v Liverpool |
| 16/04/2022 | 15:00 | Everton v Crystal Palace |
| 16/04/2022 | 15:00 | Leeds United v Chelsea |
| 16/04/2022 | 15:00 | Manchester United v Norwich City |
| 16/04/2022 | 15:00 | Newcastle United v Leicester City |
| 16/04/2022 | 15:00 | Southampton v Arsenal |
| 16/04/2022 | 15:00 | Tottenham Hotspur v Brighton |
| 16/04/2022 | 15:00 | Watford v Brentford |
| 16/04/2022 | 15:00 | West Ham United v Burnley |
| 16/04/2022 | 15:00 | Wolverhampton v Manchester City |
| 23/04/2022 | 15:00 | Arsenal v Manchester United |
| 23/04/2022 | 15:00 | Brentford v Tottenham Hotspur |
| 23/04/2022 | 15:00 | Brighton v Southampton |
| 23/04/2022 | 15:00 | Burnley v Wolverhampton |
| 23/04/2022 | 15:00 | Chelsea v West Ham United |
| 23/04/2022 | 15:00 | Crystal Palace v Leeds United |
| 23/04/2022 | 15:00 | Leicester City v Aston Villa |
| 23/04/2022 | 15:00 | Liverpool v Everton |
| 23/04/2022 | 15:00 | Manchester City v Watford |
| 23/04/2022 | 15:00 | Norwich City v Newcastle United |
| 30/04/2022 | 15:00 | Aston Villa v Norwich City |
| 30/04/2022 | 15:00 | Everton v Chelsea |
| 30/04/2022 | 15:00 | Leeds United v Manchester City |
| 30/04/2022 | 15:00 | Manchester United v Brentford |
| 30/04/2022 | 15:00 | Newcastle United v Liverpool |
| 30/04/2022 | 15:00 | Southampton v Crystal Palace |
| 30/04/2022 | 15:00 | Tottenham Hotspur v Leicester City |
| 30/04/2022 | 15:00 | Watford v Burnley |
| 30/04/2022 | 15:00 | West Ham United v Arsenal |
| 30/04/2022 | 15:00 | Wolverhampton v Brighton |
| 07/05/2022 | 15:00 | Arsenal v Leeds United |
| 07/05/2022 | 15:00 | Brentford v Southampton |
| 07/05/2022 | 15:00 | Brighton v Manchester United |
| 07/05/2022 | 15:00 | Burnley v Aston Villa |
| 07/05/2022 | 15:00 | Chelsea v Wolverhampton |
| 07/05/2022 | 15:00 | Crystal Palace v Watford |
| 07/05/2022 | 15:00 | Leicester City v Everton |
| 07/05/2022 | 15:00 | Liverpool v Tottenham Hotspur |
| 07/05/2022 | 15:00 | Manchester City v Newcastle United |
| 07/05/2022 | 15:00 | Norwich City v West Ham United |
| 15/05/2022 | 15:00 | Aston Villa v Crystal Palace |
| 15/05/2022 | 15:00 | Everton v Brentford |
| 15/05/2022 | 15:00 | Leeds United v Brighton |
| 15/05/2022 | 15:00 | Manchester United v Chelsea |
| 15/05/2022 | 15:00 | Newcastle United v Arsenal |
| 15/05/2022 | 15:00 | Southampton v Liverpool |
| 15/05/2022 | 15:00 | Tottenham Hotspur v Burnley |
| 15/05/2022 | 15:00 | Watford v Leicester City |
| 15/05/2022 | 15:00 | West Ham United v Manchester City |
| 15/05/2022 | 15:00 | Wolverhampton v Norwich City |
| 22/05/2022 | 16:00 | Arsenal v Everton |
| 22/05/2022 | 16:00 | Brentford v Leeds United |
| 22/05/2022 | 16:00 | Brighton v West Ham United |
| 22/05/2022 | 16:00 | Burnley v Newcastle United |
| 22/05/2022 | 16:00 | Chelsea v Watford |
| 22/05/2022 | 16:00 | Crystal Palace v Manchester United |
| 22/05/2022 | 16:00 | Leicester City v Southampton |
| 22/05/2022 | 16:00 | Liverpool v Wolverhampton |
| 22/05/2022 | 16:00 | Manchester City v Aston Villa |
| 22/05/2022 | 16:00 | Norwich City v Tottenham Hotspur |