Coming to the game, it was dominant tennis from Djokovic as he thrashed Tsitsipas in two sets.
Katarina Zavatska, who represented Ukraine in Billie Jean King Cup play against the US earlier this year, was the first Ukrainian player to take court on the night, partnering with Italy's Berrettini against Sakkari and Tsitsipas.
The Croatian was competing in his first tour-level final since 2020 and overcame Rafael Nadal en route to his second Masters 1000 final.
The 27-yer-old Kyrgios recovered from a set down to beat Kyrgios 6-7, 6-4, 6-4, 7-6 (7) and advanced into the quarter-final stage.
Nick Kyrgios will next face USA's B Nakashima on July 4 in the Round of 16.
The 18-year-old Spaniard took a 6-4, 5-7, 6-2 winas he cut short his Greek compatriot’s late comeback.
Andy Murray will come up against world number three Stefanos Tsitsipas in an eye-catching first round at the US Open.
Daniil Medvedev and Stefanos Tsitsipas survived three-set scares in Toronto as Rafael Nadal withdrew citing injury.
The Serbian won his 2nd ever French Open title on Sunday.
While Tsitsipas defeated Zverev in the semis, Djokovic eliminated Nadal to qualify for the finals.
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